A rule-based method for predicting the electrical activation of the heart with cardiac resynchronization therapy from non-invasive clinical data

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Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.

Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity

In vitro evaluation of fibrin mat and Tegaderm™ wound dressing for the delivery of keratinocytes-Implications of their use to treat burns

10.1016/j.burns.2007.07.009Burns342175-18

Predicting technique and patient survival over 12 months in peritoneal dialysis: the role of anxiety and depression

Background: Emotional distress is common in dialysis patients, but its role on clinical outcomes for patients on peritoneal dialysis (PD) is uncertain. Purpose: To evaluate the effect of depression and anxiety on 1-year prognosis in PD patients. Methods: A total of N = 201 PD patients (58.9 ± 12.59 years) completed the Hospital Anxiety Depression Scale and measures of social support at baseline and were followed up for CC technique and actuarial patient survival. Results: Mortality and technique failure rates were 9.9 and 5.97 %, respectively. Carer-assisted PD, anxiety, comorbid burden and albumin were significant univariate predictors. Multivariate proportional hazard model to adjust for confounders indicated that anxiety remained significant with HR of 2.145 [95 % CI 1.03, 4.49, p = 0.043] for death/technique failure. Conclusion: Anxiety is an important predictor of actuarial and technique survival in PD. Effective treatment for symptoms of anxiety may represent an easily achievable means of improving the clinical outcome of PD patients. © 2015, Springer Science+Business Media Dordrecht

Rates of intentional and unintentional nonadherence to peritoneal dialysis regimes and associated factors

10.1371/journal.pone.0149784PLoS ONE112e014978

Erratum to: Predicting technique and patient survival over 12 months in peritoneal dialysis: the role of anxiety and depression(Int Urol Nephrol, Doi:10.1007/s11255-015-1191-x)

[No abstract available

Factors associated with prolonged length of stay for elective hepatobiliary and neurosurgery patients: a retrospective medical record review

10.1186/s12913-017-2817-8BMC health services research181

Breast cancer resistance protein identifies clonogenic keratinocytes in human interfollicular epidermis

10.1186/s13287-015-0032-2Stem Cell Research and Therapy613